After my teaching profession for graduate students in Biochemistry for 7 years pursued a research career in Ocular Biochemistry in the Department of Biochemistry and Cell Biology, Vision Research foundation (since 2002).
In addition, acting as Quality Manager in SNSC clinical Laboratory services, Medical Research Foundation at SankaraNethralaya, Chennai (Honorary service).
My research work focuses on delineating mechanistic pathways of ocular diseases using cell based models and clinical studies. This is to understand the etiopathogensis of specific ocular diseases and to identify drug targets for intervention. The work also focusses on characterizing potential therapeutic molecules including ayurvedic principles of Triphala.
PubMed link
https://www.ncbi.nlm.nih.gov/pubmed/?term=Narayanasamy+Angayarkanni
Education :
M.Sc, M.phil& PhD – Medical Biochemistry, (1996), DR.ALMPGIBMS, University of Madras
B.Sc Biochemistry at Avinashilingam Home science college, Coimbatore
Publications: 53
Book Chapters: 4
Book: 1
Patent: 1; Filed:1
Guided 5Ph.D students
60 post graduated Dissertations
Completed projects: As PI is15
On going :3
Biomarker discovery : Towards diagnostic
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Tear based clinical proteomics for Biomarker discovery towards early diagnosis and treatment of Dry Eye Syndrome. Currently focusing to characterize candidate biomarkers.
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Prognostic and early markers for development of Diabetic retinopathy in type 2 Diabetes mellitus
Delineating disease pathogenesis for novel drug targets :
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Protective role of HDL associated anti-oxidant Paroxonase enzyme in the retinal barrier cell : what happens in AMD?
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Elastosis defect in understanding the pathology of Pseudoexfoliation syndrome.
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Steven Johnson syndrome : Inflammatory cytokines and fibrosis in the ocular surface.
Characterization of potential therapeutic Ayurvedic principle compounds / aminoacids
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Signaling mechanism of Triphala active principles that showed characteristic anti-fibrotic, anti-angiogenic and anti-inflammatory activities based on retinal barrier cell and vascular cell based models.
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Signaling mechanism of amino acids in potentiating GLUT4 mediated glucose uptake and mechanism of action of amino acids in ameliorating the retinal changes in Diabetic retinopathy.
Google Scholar :
Check out this link
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Rebecca, M., Gayathri, R., Bhuvanasundar, R., Sripriya, K., Shantha, B., & Angayarkanni, N*. (2018). Elastin modulation and modification by homocysteine: a key factor in the pathogenesis of Pseudoexfoliation syndrome?. British Journal of Ophthalmology, bjophthalmol-2018. DOI: 10.1136/2018 - 312088
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Shanmuganathan, S., & Angayarkanni, N*. (2019). Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation. Microvascular research, 121, 14-23. DOI: 10.1016/j.mvr.2018.09.001.
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Iyer, G., Agarwal, S., Srinivasan, B., & Narayanasamy, Angayarkanni. (2018). Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis. Indian journal of ophthalmology, 66(8), 1084. DOI: 10.4103/ijo.IJO_82_18.
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Shanmuganathan, S., & Angayarkanni, N*. (2018). Chebulagic acid Chebulinic acid and Gallic acid, the active principles of Triphala, inhibit TNFα induced pro-angiogenic and pro-inflammatory activities in retinal capillary endothelial cells by inhibiting p38, ERK and NFkB phosphorylation. Vascular pharmacology. DOI: 10.1016/j.vph.2018.04.005.
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Srividya, G., Jain, M., Mahalakshmi, K., Gayathri, S., Raman, R., & Angayarkanni, N*. (2018). A novel and less invasive technique to assess cytokine profile of vitreous in patients of diabetic macular oedema. Eye, 32(4), 820. DOI: 10.1038/eye.2017.285.
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Muralikumar, S., Vetrivel, U., Narayanasamy, Angayarkanni., & Das, U. N. (2017). Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. Lipids in health and disease, 16(1), 17. 10.1186/s12944-016-0404-3.
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Selvi, R., Bhuvanasundar, R., & Angayarkanni, N*. (2017). Amino Acid Mixture Acts as a Potent VEGF Lowering Agent in CHO-K1 Cells Exposed to High Glucose. Archives of medical research, 48(3), 238-246. DOI: 10.1016/j.arcmed.2017.05.001.
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Gurumurthy, S., Iyer, G., Srinivasan, B., Agarwal, S., & Angayarkanni, N*. (2018). Ocular surface cytokine profile in chronic Stevens-Johnson syndrome and its response to mucous membrane grafting for lid margin keratinisation. British Journal of Ophthalmology, 102(2), 169-176. DOI: 10.1136/bjophthalmol-2017-310373
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Indhushree, R., Monica, R., Coral, K., Angayarkanni, N., Punitham, R., Subburathinam, B. M., ... & Santanam, P. P. (2016). Visual functions of workers exposed to organic solvents in petrochemical industries. Indian journal of occupational and environmental medicine, 20(3), 133. DOI: 10.4103/0019-5278.203138.
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Aluru, S. V., Shweta, A., Bhaskar, S., Geetha, K., Sivakumar, R. M., Utpal, T, Prema P, Sivakumar M. & Angayarkanni, N*. (2017). Tear fluid protein changes in dry eye syndrome associated with rheumatoid arthritis: a proteomic approach. The ocular surface, 15(1), 112-129. DOI: 10.1016/j.jtos.2016.09.005.
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AnandBabu, K., Bharathidevi, S. R., Sripriya, S., Sen, P., Prakash, V. J., Bindu, A.Viswanathan N & Angayarkanni, N*. (2016). Serum Paraoxonase activity in relation to lipid profile in Age-related Macular Degeneration patients. Experimental eye research, 152, 100-112. DOI: 10.1016/j.exer.2016.09.009.
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Gayathri, R., Coral, K., Sharmila, F., Sripriya, S., Sripriya, K., Manish, P., ... & Narayanasamy, Angayarkanni*. (2016). Correlation of aqueous humor Lysyl oxidase activity with TGF-ß levels and LOXL1 genotype in Pseudoexfoliation. Current eye research, 41(10), 1331-1338. DOI: 10.3109/02713683.2015.1125505.
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Sivasankar, S., Lavanya, R., Brindha, P., & Angayarkanni, N*. (2015). Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PloS one, 10(3), e0120512. DOI: 10.4103/ijmr.IJMR_1583_15.
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Bharathidevi, S. R., Babu, K. A., Jain, N., Muthukumaran, S., Umashankar, V., Biswas, J., & Angayarkanni, N*. (2017). Ocular distribution of antioxidant enzyme paraoxonase & its alteration in cataractous lens & diabetic retina. The Indian journal of medical research, 145(4), 513. DOI: 10.4103/ijmr.IJMR_1284_14..
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Bharathselvi, M., Biswas, S., Raman, R., Selvi, R., Coral, K., Narayanansamy, Angayarkanni, Ramakrishnan S & Sulochana, K. N. (2016). Homocysteine & its metabolite homocysteine-thiolactone & deficiency of copper in patients with age related macular degeneration-A pilot study. The Indian journal of medical research, 143(6), 756. DOI: 10.4103/0971-5916.192026.
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Kaviarasan, K., Jithu, M., Mulla, M. A., Sharma, T., Sivasankar, S., Das, U. N., & Angayarkanni, N*. (2015). Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy. Metabolism, 64(9), 958-966. DOI: 10.1016/j.metabol.2015.04.005.
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Bharathi Devi, S. R., Coral, K., Sulochana, K. N., & Angayarkanni, N*. (2015). Free Amino Acids Glycine and Glutamic Acid Inhibit Angiogenesis Induced by AGE in Bovine Retinal Endothelial Cells. J Glycomics Lipidomics 5: 130. doi: 10.4172/2153-0637.1000130 DOI: 10.4172/2153-0637.1000130.
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Coral, K., Madhavan, J., Pukhraj, R., & Angayarkanni, N*. (2013). High glucose induced differential expression of lysyl oxidase and its isoform in ARPE-19 cells. Current eye research, 38(1), 194-203. DOI: 10.3109/02713683.2012.720341.
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Arora, B., Narayanasamy Angayarkanni., Nirmal, J., Halder, N., Patnaik, S., Ravi, A. K., & Velpandian, T. (2014). Development and validation of a LC–MS/MS method for homocysteine thiolactone in plasma and evaluation of its stability in plasma samples. Journal of Chromatography B, 944, 49-54. DOI: 10.1016/j.jchromb.2013.11.011.
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Jasna, J. M., Anandbabu, K., Bharathi, S. R., & Angayarkanni, N*. (2014). Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult. PloS one, 9(6), e101380. DOI: 10.1371/journal.pone.0101380.
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Sivasankar, S., Lavanya, R., Brindha, P., & Angayarkanni, N*. (2015). Aqueous and alcoholic extracts of Triphala and their active compounds chebulagic acid and chebulinic acid prevented epithelial to mesenchymal transition in retinal pigment epithelial cells, by inhibiting SMAD-3 phosphorylation. PloS one, 10(3), e0120512. DOI: 10.1371/journal.pone.0120512.
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Agarwal, S., Angayarkanni, N., Iyer, G., Srinivasan, B., Natarajan, R., Charola, S., ... & Padmanabhan, P. (2014). Clinico-biochemical correlation of the effect of subconjunctival bevacizumab for corneal neovascularization. Cornea, 33(10), 1016-1021. DOI: 10.1097/ICO.0000000000000198.
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Biswas, J., Ravi, R. K., Naryanasamy, Angayarkanni., Kulandai, L. T., & Madhavan, H. N. (2013). Eales' disease-current concepts in diagnosis and management. Journal of ophthalmic inflammation and infection, 3(1), 11. DOI: 10.1186/1869-5760-3-11.
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Aluru, Saijyothi. V., Agarwal, S., Srinivasan, B., Iyer, G. K., Rajappa, S. M., Tatu, U, Prema P, Nirmala S & Narayanasamy, Angayarkanni*. (2012). Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. PloS one, 7(12), e51979. DOI: 10.1371/journal.pone.0051979.
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Bharathselvi, M., Biswas, J., Selvi, R., Coral, K., Narayanasamy, Angayarkanni., Ramakrishnan, S., & Sulochana, K. N. (2013). Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales’ disease. Annals of clinical biochemistry, 50(4), 330-338.
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Vetrivel, U., Ravichandran, S. B., Kuppan, K., Mohanlal, J., Das, U. N., & Narayanasamy Angayarkanni*. (2012). Agonistic effect of polyunsaturated fatty acids (PUFAs) and its metabolites on brain-derived neurotrophic factor (BDNF) through molecular docking simulation. Lipids in health and disease, 11(1), 109. DOI: 10.1186/1476-511X-11-109.
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Selvi, R., Bhuvanasundar, R., Saijyothi, A. V., Sulochana, K. N., & Angayarkanni, N*. (2012). Amino acids potentiate insulin signaling in CHO-K1 at high glucose conditions. Archives of medical research, 43(3), 173-182. DOI: 10.1016/j.arcmed.2012.04.008.
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Devi, S. R. B., Suganeswari, G., Sharma, T., Thennarasu, M., & Angayarkanni, N*. (2012). Homocysteine induces oxidative stress in young adult central retinal vein occlusion. British Journal of Ophthalmology, bjophthalmol-2011. DOI: 10.1136/bjophthalmol-2011-301370.
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Saijyothi, A. V., Fowjana, J., Madhumathi, S., Rajeshwari, M., Thennarasu, M., Prema, P., & Angayarkanni, N*. (2012). Tear fluid small molecular antioxidants profiling shows lowered glutathione in keratoconus. Experimental eye research, 103, 41-46. DOI: 10.1016/j.exer.2012.07.010.
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Selvi, R., Angayarkanni, N*., Biswas, J., & Ramakrishnan, S. (2011). Total antioxidant capacity in Eales’ disease, uveitis & cataract. The Indian journal of medical research, 134(1), 83.
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Barathi, S., Charanya, M., Muthukumaran, S., Angayarkanni, N*., & Umashankar, V. (2010). Comparative modeling of PON2 and analysis of its substrate binding interactions using computational methods. Journal of ocular biology, diseases, and informatics, 3(2), 64-72. DOI: 10.1007/s12177-011-9057-7.
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Barathi, S., Angayarkanni, N*., & Sumantran, V. N. (2010). GLUT-1 expression in bovine retinal capillary endothelial cells and pericytes exposed to advanced glycation end products. Investigative ophthalmology & visual science, 51(12), 6810-6814. DOI: 10.1167/iovs.10-5312.
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Saijyothi, A. V., Angayarkanni, N*., Syama, C., Utpal, T., Shweta, A., Bhaskar, S.Thennarasu,M Rajappa S & Prema, P. (2010). Two dimensional electrophoretic analysis of human tears: collection method in dry eye syndrome. Electrophoresis, 31(20), 3420-3427. DOI: 10.1002/elps.201000271.
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Verma, A., Biswas, J., Radhakrishnan, S., & Narayanasamy, A. (2010). Intra-ocular expression of vascular endothelial growth factor (VEGF) and pigment epithelial-derived factor (PEDF) in a case of Eales’ disease by immunohistochemical analysis: a case report. International ophthalmology, 30(4), 429-434. DOI: 10.1007/s10792-009-9338-3.
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Selvi, R., Angayarkanni, N*., Asma, B., Seethalakshmi, T., & Vidhya, S. (2010). Amino acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions. Molecular and cellular biochemistry, 344(1-2), 43-53. DOI: 10.1007/s11010-010-0527-1.
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Barathi, S., Angayarkanni, N*., Pasupathi, A., Natarajan, S. K., Pukraj, R., Dhupper, M., ... & Sivashanmugham, M. (2010). Homocysteinethiolactone and paraoxonase: novel markers of diabetic retinopathy. Diabetes care, 33(9), 2031-2037. DOI: 10.2337/dc10-0132.
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Angayarkanni, N*., Selvi, R., Pukhraj, R., Biswas, J., Bhavesh, S. J., & Tombran-Tink, J. (2009). Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. Journal of ocular biology, diseases, and informatics, 2(1), 20-28. DOI: 10.1007/s12177-009-9017-7.
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Venkata, S. J. A., Narayanasamy, Angayarkanni*., Srinivasan, V., Iyer, G. K., Sivaramakrishnan, R., Subramanian, M., & Mahadevan, Rajeshwari. (2009). Tear ascorbic acid levels and the total antioxidant status in contact lens wearers: a pilot study. Indian journal of ophthalmology, 57(4), 289. DOI: 10.4103/0301-4738.53054.
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Jaichandran, V. V., Angayarkanni, N., Karunakaran, C., Bhanulakshmi, I. M., & Jagadeesh, V. (2008). Diffusion of Lidocaine buffered to an optimal pH across the Endotracheal tube cuff-An in-Vitro study. Indian Journal of Anaesthesia, 52(5), 536.
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Coral, K., Angayarkanni, N*, Gomathy, N., Bharathselvi, M., Pukhraj, R., & Rupak, R. (2009). Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase. Investigative ophthalmology & visual science, 50(8), 3607-3612. DOI: 10.1167/iovs.08-2667.
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Coral, K., Angayarkanni, N*., Madhavan, J., Bharathselvi, M., Ramakrishnan, S., Nandi, K., ... & Krishnakumar, S. (2008). Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment. Investigative ophthalmology & visual science, 49(11), 4746-4752. DOI: 10.1167/iovs.07-1550.
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Angayarkanni, N*., Barathi, S., Seethalakshmi, T., Punitham, R., Sivaramakrishna, R., Suganeswari, G., & Tarun, S. (2008). Serum PON1 arylesterase activity in relation to hyperhomocysteinaemia and oxidative stress in young adult central retinal venous occlusion patients. Eye, 22(7), 969. DOI: 10.1038/sj.eye.6703062.
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Selvi, R., Angayarkanni, N., Bharathselvi, M., Sivaramakrishna, R., Anisha, T., Jyotirmoy, B., & Vasanthi, B. (2007). Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. Current eye research, 32(7-8), 677-683. DOI: 10.1080/02713680701486402.
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Barathi, S., Vadhana, P., Angayarkanni, N*., & Ramakrishnan, S. (2007). Estimation of hydrogen sulphide in the human lymphocytes. IJBB 44(3) (2007) 179-182.
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Narayanasamy, A*., Subramaniam, Barathi., Karunakaran, Coral., Ranganathan, Punitham., Sivaramakrishnan, R., Sharma, T., Vasanthi S & Roy, Joseph. (2007). Hyperhomocysteinemia and low methionine stress are risk factors for central retinal venous occlusion in an Indian population. Investigative ophthalmology & visual science, 48(4), 1441-1446. DOI: 10.1167/iovs.06-0905.
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Ramakrishnan, S., Sulochana, K. N., Lakshmi, S., Selvi, R., & Angayarkanni, N. (2006). Biochemistry of homocysteine in health and diseases.
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Coral, K., Raman, R., Rathi, S., Rajesh, M., Sulochana, K. N., Angayarkanni, N., ... & Ramakrishnan, S. (2006). Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration. Eye, 20(2), 203. DOI: 10.1038/sj.eye.6701853.
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Sulochana, K. N., Ramprasad, S., Coral, K., Lakshmi, S., Punitham, R., Narayanasamy, Angayarkanni., & Ramakrishnan, S. (2003). Glycation and glycoxidation studies in vitro on isolated human vitreous collagen. Medical Science Monitor, 9(6), BR220-BR224.
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Angayarkanni, N., & Selvam, R. (1999). Effect of γ-Glutamyl Carboxylation of Renal Microsomes on Calcium Oxalate MonohydrateCrystal Binding in Hyperoxaluria. Nephron, 81(3), 342-346. DOI: 10.1159/000045303.
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Angayarkanni, N., & Selvam, R. (1998). Enhanced renal vitamin-K-dependent gamma-glutamyl carboxylase activity in experimental rat urolithiasis. European urology, 33(1), 116-120. DOI: 10.1159/000019523.
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Selvam, R., Angayarkanni, N., & Vijaya, R. (1996). NUCLEAR OXALATE BINDING PROTEINS OF RAT LIVER NUCLEI: A PRELIMINARY REPORT. Medical science research, 24(4). DOI: ..
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Selvam, R., Subramanian, L., Gayathri, R., & Angayarkanni, N. (1995). The anti-oxidant activity of turmeric (Curcuma longa). Journal of ethnopharmacology, 47(2), 59-67. DOI: 10.1016/0378-8741(95)01250-H.
2011
SwarnalathaPunshi Award for the Best Basic Science Researcher at Vision Research Foundation
2010
ICMR overseas fellowship for Biomedical scientists done at Univ of New Mexico. USA
2013
DBT-CETP Travel fellowship 2013 for attending ARVO meeting at Seattle, USA
2007
Allergan Travel fellowship : ASIA -ARVO 2007 at Singapore
1996
Awarded the Research Associate ship by CSIR
1994
Received the PGIBMS Award-Gold Medal for Best Paper presentation at the Indian Association of Biomedical Scientists
1994
Received Senior Research Fellowship by the CSIR
1993
Young Scientist Award by the Urolithiasis Society of India
1992
Qualified CSIR-UGC National Level Test for eligibility for Lectureship in Life Sciences in University / Colleges
1990
Awarded GATE Scholarship in life sciences ( 91 percentile) as JRF to do Ph.D. in a major project approved by the University Grants Commission (UGC)
Post Doctoral Fellows
Dr Mani
Novartis (current)
Dr Srivdiya Gurumurthy
Dr Kaviarasan K
Post Doctoral Fellows
Mr Vignesh
ICMR 2018 (current)
Ms Sneha
CSIR 2017 (current)
Mr Sivasankar S
CSIR 2013
Ms Jasna M
ICMR 2010
Mr Jithu M
DBT 2010
Ms. Sai jyothi A V
DBT 2008
Ms Barathi Devi S
ICMR 2006
Ms Selvi R
DST 2005, 2009
Ms K Coral
DBT 2005
Project JRF
Ms. Vijayvani
DST-SERB 2017 (current)
Mr. Anandbabu
DBT 2011
Mr Sanket C
ICMR 2012
Ms Sivasankari
Mr Sivasankar S
CSIR 2010
Ms Gayathri R
ICMR 2008
INSPIRE Fellow
Ms.Rebecca M
DST Fellowship 2015 (current)
Project Assistant
Ms.Nandhini
Novartis 2018 (current)
On going : PhD students
Mr Anandbabu
(SASTRA Univ)
Ms Rebecca
(TN MGR Med Univ)
Completed Ph.D
Dr. Coral K
BITS Pilani 2008
Dr Barathi Devi S R
BITS Pilani 2010
Dr Selvi R
BITS Pilani 2012
Dr Saijyothi A V
BITS Pilani 2013
Dr Sivasankar S
SASTRA Thanjavur 2018
Dr N Angayarkanni, PhD
Professor and Head
RS Mehta Jain Department of Biochemistry and Cell Biology
Vision Research Foundation,
41/18 College Road, Nungambakkam
Chennai – 600 006.
Ph: +91-(044) 28271616 Extn: 1341 / 1301
Email: drak@snmail.org